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KMID : 0648320000060020109
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Journal of The Korean Society of Hypertension
2000 Volume.6 No. 2 p.109 ~ p.119
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Antihypertensive Efficacy and Safety of Losartan(Cozaar®) in Patients with Essential Hypertension
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Kim Jae-Hyung
Choi Kyu-Bo
Park In-Soo
Chae Jang-Seong
Kim Chul-Min
Rho Tae-Ho
Kim Chong-Jin
Seung Ki-Bae
Chung Wook-Sung
Lee Man-Young
Kang Dong-Heon
Baek Sang-Heung
Youn Ho-Joong
Lee Gil-Hwan
Jeon Doo-Su
Oh Yong-Seog
You Ki-Dong
Jeon Hui-Kyung
Park Ji-Won
Kim Hee-Yeol
Chang Ki-Yuk
Rhim Hyou-young
Moon Keon-Woong
Jung Hae-Ok
Lee Jong-Min
Ihm Sang-Hyun
Cho Eun-Ju
Kim Hee-Yeol
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Abstract
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Background: Losartan potassium, an orally active and highly selective antagonist of angiotensin II at the type I receptor. The purpose of this study is to evaluate the efficacy and safety of losartan in patients with essential hypertension.
Methods: After the wash-out periods of two weeks duration, 50 ㎎ losartan once per day was administered orally for 10 weeks in 179 patients with state 1-3 hypertension. If sitting diastolic blood pressure was equal to or greater 90 ㎜Hg after a 6 weeks treatment period, the dosage was doubled until the end of study (10 week).
Results: After 10 weeks treatment, mean reductions in sitting systolic and diastolic blood pressure were 24.1±18.5 ㎜Hg (95% confidence interval 21.4~26.9), 14.3±13.7 ㎜Hg (95% confidence interval 12.3~16.3), respectively. There were
significant differences in mean sitting systolic and diastolic pressure between baseline and 10th week (p<0.001). After 10 weeks treatment, one hundred of 179 patients (55.8%) showed sitting diastolic pressure below 90 ㎜Hg and one hundred thirty-seven (76.5%) of 179 patients had an excellent or good antihypertensive response (sitting diastolic blood pressure < 90 ㎜Hg or ≥ 90 ㎜Hg with a reduction of 10 ㎜Hg or more). Losartan was well tolerated without significant adverse event. Laboratory parameters were not chaged significantly.
Conclusion: The administration of losartan once daily was well tolerated and produced significant reductions in blood pressure in hypertensive patients.
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KEYWORD
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Losartan, Hypertension,
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